Número Especial em homenagem ao
Prof. Angelo da Cunha Pinto
A Diretoria e o Conselho da Sociedade Brasileira de Química (SBQ), em consonância com as Publicações da Sociedade, decidiram editar o primeiro número especial da PubliSBQ, em homenagem ao Ex-Presidente e Professor Angelo da Cunha Pinto, que teve atuação destacada na SBQ e na criação e/ou editoria das suas publicações. Em realidade, este número especial é uma comemoração da vida luminosa do Angelo entre nós.
Para organizar este número especial convidamos as (os) colegas a submeter artigos científicos originais, revisões, trabalhos de divulgação científica, notas técnicas e artigos educacionais, de acordo com a linha editorial de cada publicação, para a Química Nova, Química Nova na Escola, Revista Virtual de Química, Química Nova Interativa, e Journal of the Brazilian Chemical Society.
Natural Products
Rev. Virtual Quim. 2017
Validação de Métodos por CG-EM para Análise de Carvacrol e trans-β-Cariofileno em Amostras Comerciais Contendo Óleos Essenciais
Francisco Carlos de Oliveira, André Luiz M. Camelo, Francisco Felipe M. da Silva, Francisco Thiago C. de Souza, Elisane Longhinotti, Francisco Geraldo Barbosa, Ronaldo F. Nascimento
Carvacrol and trans-β-caryophyllene are widely found several medicinal plants, being assigned to these compounds various pharmacological properties. Therefore, this work presents a validation method for these compounds in the species of Lippia sidoides and Rosmarinus officinalis and a copaiba oil sample available in popular trade in Fortaleza. Thus, essential oil samples were diluted and analyzed in a gas chromatograph with mass spectrometric detector (GC-MS). Validation parameters showed satisfactory values, such as linearity, lower limit of detection and quantitation, reproducibility at different days (inter day) considerable analysis and recovery values. Of the compounds studied, the Lippia sidoides species presented a percentage of 32.01 of carvacrol and 1.78 of trans-β-caryophyllene, respectively. To R. officinales found a percentage of 0.28 and 0.34 respectively for carvacrol and trans-β-caryophyllene. For oil copaiba not logged carvacrol, however, the trans-β-caryophyllene, was present in amount of, 74.5%. With the results, the method can be considered as a useful analytical tool for quality control of trans-β-caryophyllene and carvacrol and the derivatives in the essential oils.
Quim. Nova 2017
Triterpenoides, fenólicos e efeito fitotóxico das folhas de Eugenia flavescens DC (Myrtaceae)
Antonio J. Cantanhede Filho, Lourivaldo S. Santos, Giselle M. S. P. Guilhon, Maria das Graças B. Zoghbi, Pollyane S. Ports e Iris C. S. Rodrigues
This article reports the chemical study, LC/MS phenolic profile and phytotoxic effect from Eugenia flavescens, a plant native to Northern Brazil.
J. Braz. Chem. Soc. 2017
The Chemistry of the Sesquiterpene Alkaloids
Timothy J. Brocksom, Kleber T. de Oliveira and André L. Desiderá
This review presents the occurrence, structures, biological activities, biosynthesis, and syntheses of the
sesquiterpene alkaloids, principally the dendrobine and guaipyridine groups.
Rev. Virtual Quim 2017
Química de Produtos Naturais: Plantas que Testemunham Histórias
Márcia R. Almeida; Sabrina T. Martinez; Angelo C. Pinto
The botanical description of plants, classification and use of some of them as medicine to treat typical diseases of Brazilian regions may be accompanied by reports described in historical records and botanical expeditions of adventurers and research of physicians and pharmacists. These were primarily responsible for discoveries that are still remembered and rethought for the development of potential drugs from these plants. This work presents a list of plants and their applications and uses by different
people with the evolution of history.
Quim. Nova 2017
One strain-many compounds (OSMAC) method for production of phenolic compounds using Camarops sp., an endophytic fungus from Alibertia macrophylla (Rubiaceae)
Juliana R. Gubiani, Thomas R. Habeck, Vanessa M. Chapla, Geraldo H. Silva, Vanderlan S. Bolzani and Angela R. Araujo
Endophytic fungus Camarops sp. isolated from the leaves of Alibertia macrophylla, was used to produce seven phenolic derivatives through the one strain-many compounds (OSMAC) approach and identified by 2D NMR and HRESIMS spectra.
Rev. Virtual Quim. 2017
Óleos Essenciais dos Frutos e Folhas de Kielmeyera coriacea: Atividade Antitumoral e Estudo Químico
Raiane S. Lemes, Géssica Carla S. Costa, Douglas Carlos S. Silva, Amanda B. Becceneri, Keylla U. Bicalho, Mayker Lazaro D. Miranda, Vania S. S. Diniz, Cristiane M. Cazal
Kielmeyera coriacea, a typical tree species of the Cerrado (Brazilian Savanna), popularly known as “pausanto" and it is used in traditional medicine for the treatment of various diseases. This study aimed to chemically characterize the essential oils of leaves and fruits of K. coriacea and to evaluate its antitumor activity against human tumor cell lines MDA-MB-231 (breast tumor) and DU-145 (prostate tumor) as a way to search for new drugs derived from natural sources. Essential oils were extracted by hydrodistillation in Clevenger. The average yield of essential oil of leaves and fruits was 0.38% and 0.0041%, respectively. In leaves from K. coriacea, the major compounds found in the essential oils, were geranyl linalool (27,78), 2- Acetate (2E) Tridecenol (9.06%), E-nerolidol (7.70%) and α-bisabolol (5,09). The major compounds found in essential oils of fruits were D-germacrene (18.94%), neointermedeol (12.18%), bicyclogermacrene (12.00%), Viridiflorol (9,30 %), Globulol (8,76%), Epi-α-muurolol (8,13%) and δ-cadinene (5,00%).. The essential oils of fruits inhibited the proliferation of tumor cell lines DU-145 and MDAMB-231, as well as of the non-tumor cells (FH -Human fibroblasts). By contrast the essential oils of leaves were not active in any tested tumor lineage. To our knowledge, this is the first report on the chemical composition and antitumor activity of this species, and it clearly enhance our chemical knowledge of this plant.
Rev. Virtual Quim. 2017
Óleo Essencial das Flores de Eugenia klotzschiana (Myrtaceae): Composição Química e Atividades Tripanocida e Citotóxica In Vitro
Nárgella S. Carneiro, José Milton Alves, Cassia Cristina F. Alves, Viviane R. Esperandim, Mayker Lazaro D. Miranda
Chagas disease, which is caused by Trypanosoma cruzi, has been commonly treated by nifurtimox and benzonidazole, two drugs that cause several side effects. As a result, the use of natural products for treating neglected diseases has increased in recent years and plants have become a promising alternative to developing new medicines. Therefore, this study aimed to determine the chemical composition of the essential oil from fresh flowers of Eugenia klotzchiana and to evaluate for the first time its trypanocidal and cytotoxic potential in vitro. The essential oil from the fresh flowers was obtained by hydrodistillation carried out by a Clevenger apparatus and its chemical composition was determined by GC-MS. The main compounds found in the essential oil were sesquiterpenoids: β-caryophyllene (21.1%), bicyclogermacrene (10.2%) and spathulenol (20.9%). Results showed that the essential oil had strong trypanocidal activity against the trypomastigote forms of Trypanosoma cruzi (IC50 = 20.2 μg/mL) and moderate cytotoxicity against fibroblasts in the concentration range (CC50 = 220.3 μg/mL). In short, the essential oil from fresh flowers of Eugenia klotzchiana can be considered a new source of bioactive compounds for the development of antiparasitic drugs.
Quim. Nova 2017
HS-SPME as an efficient tool for discriminating chemotypes of Lippia alba (Mill.) N. E. Brown
Aiêrta C. C. da Silva, Francisco G. Barbosa, Jair Mafezoli, Maria da C. F. de Oliveira e Terezinha F. de Oliveira
HS-SPME was used to distinguish three chemotypes of Lippia alba and compared with the traditional hydrodistillation method.
Rev. Virtual Quim. 2017
Flavonoides e Atividade Antioxidante das Folhas de Bauhinia longifolia (Bong.) Steud.
Alda Ernestina dos Santos, Cleber B. Barreto Junior, Ricardo M. Kuster
In this study the chemical composition of Bauhinia longifolia leaves was evaluated. The phytochemical study of the methanolic extract from the leaves of B. longifolia led to the isolation and structural elucidation of aglycone quercetin and its 3-O-monoglycoside derivatives: quercetin-3-O-α-arabinofuranoside, quercetin-3-O-α- rhamnopyranoside, quercetin-3-O-β-glucopyranoside and quercetin-3-O-β-galactopyranoside. Flavonoid structures were determined using a combination of techniques, including HPLC-UV, ESI-MS and NMR, in addition to the literature data. The antioxidant activity of the hexane, dichloromethane, ethyl acetate (EtOAc) and butanol (BuOH) fractions from the partition of the methanolic extract from the leaves of B. longifolia was evaluated by the DPPH radical reduction method and expressed in terms of its CE50. The highest antioxidant activity was observed for EtOAc fractions (CE50 = 21.2 μg/mL) and BuOH (CE50 = 16.1 μg /mL) fractions. They were also evaluated for total phenol content by the Folin-Ciocalteau spectrophotometric method, which revealed high concentrations of phenolic compound in EtOAC (393.8 μg EAG/mg) and BuOH (422.4 μg EAG/mg) and low total phenolic content in hexane (23.8 μg EAG/mg) and dichloromethane (61.9 μg EAG / mg) fractions. For the first time the antioxidant activity of B. longifolia leaves is reported, as well as the presence of the monoglycosides avicularin, hyperin and isoquercitrin, flavonoid commun on Bauhinia genus, but never described for B. longifolia. Thus the present study contributes with the chemical and pharmacological knowledge of B. longifolia, a great medicinal importance specie.
Quim. Nova 2017
Cyclo-(trp-phe) diketopiperazines from the endophytic fungus Aspergillus versicolor isolated from Piper aduncum
Juliana R. Gubiania, Helder L. Telesb, Geraldo H. Silvac, Maria Cláudia M. Youngd, José O. Pereirae, Vanderlan S. Bolzania and Angela R. Araujoa
An endophytic fungus A. versicolor isolated from the leaves of P. aduncum was used to produce six known compounds: three peptide derivatives, one adenine derivative, onebenzoic acid derivative.
J. Braz. Chem. Soc. 2017
Copaiba Oil and Its Constituent Copalic Acid as Chemotherapeutic Agents against Dermatophytes
Marcela T. Nakamura, Eliana H. Endo, João Paulo B. de Sousa, Daniel R. Callejon, Tânia Ueda-Nakamura, Benedito P. Dias Filho, Osvaldo de Freitas, Celso V. Nakamura and Norberto P. Lopes
Copalic acid activity against dermatophytes Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum gypseum.
Quim. Nova 2017
Constituintes químicos e atividade antioxidante in vivo de flavonoides isolados de Clusia lanceolata (Clusiaceae)
Rafaela O. Ferreira, Almir R. de Carvalho Junior, Cristiano J. Riger, Rosane N. Castro, Tania M. S. da Silva e Mário G. de Carvalho
Flavonoid C-glycosides and phaeophytins from Clusia lanceolata. Vitexin derivatives with in vivo antioxidant activity.
Quim. Nova 2017
Composição química, atividade citotóxica e antioxidante de um tipo de própolis da Bahia
Darlan C. dos Santos, Jorge Mauricio David e Juceni Pereira David
Saturated hydrocarbons, methyl cinnamate, sitosterol cinnamate and ananixanthone were isolated from the brown propolis (classified as Propolis Type 6). The extracts showed toxicity in the brine shrimp test.
Quim. Nova 2016
Comparação entre a composição química e capacidade antioxidante de diferentes extratos de própolis verde
Fernanda B. Salgueiro e Rosane N. Castro
A multivariate analysis of chemical composition of commercial and in natura Brazilian green propolis.
J. Braz. Chem. Soc. 2017
Chemical Constituents of Psychotria nemorosa Gardner and Antinociceptive Activity
Nivea O. Calixto, Millena S. Cordeiro, Thais B. S. Giorno, Gibson G. Oliveira, Norberto P. Lopes, Patricia D. Fernandes, Angelo C. Pinto and Claudia M. Rezende
This is the first phytochemical study of Psychotria nemorosa Gardner leaves (Rubiaceae) established in a metabolomic perspective by GC-MS and LC-MS, besides its antinociceptive activity.
J. Braz. Chem. Soc. 2017
Brazoides A-D, New Alkaloids from Justicia gendarussa Burm. F. Species
Luciana G. S. Souza, Macia C. S. Almeida, Telma L. G. Lemos, Paulo R. V. Ribeiro, Kirley M. Canuto, Raimundo Braz-Filho, Catarina N. Del Cistia, Carlos Mauricio R. Sant’Anna, Francisco S. Barreto and Manoel O. de Moraes
Four new alkaloids, named Brazoides A-D, together with three known compounds were isolated from Justicia gendarussa Burm. F. (Acanthaceae).
Quim. Nova 2017
Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifoli
Amira Arciniegas, Ana L. Pérez-Castorena, Antonio Nieto-Camacho, Yuko Kita and Alfonso Romo de Vivar
The acetone extracts of S. acuta and S. rhombifolia inhibited yeast α-glucosidase (IC50 8.49 ± 0.66 and 8.10 ± 0.34 μg mL-1, respectively) and showed mild activity on DPPH and Tcompounds 5 was active in all evaluations.
J. Braz. Chem. Soc. 2017
Angelocunhol: New Erythroxylane Diterpene and Other Compounds from Simira sampaioana (Rubiaceae)
Vinicius F. Moreira, Ivo J. C. Vieira and Raimundo Braz-Filho
A new erythroxylane diterpene, named angelocunhol, was characterized together with 14 known compounds from the Simira sampaioana (Rubiaceae) wood.
Rev. Virtual Quim. 2017
Screening Fitoquímico e Avaliação da Toxicidade de Croton heliotropiifolius Kunth (Euphorbiacea) frente à Artemia salina Leach
Jéssica A. G. Silva, Izabela R. Lima, Marllon Alex N. Santana, Tainá Maria S. da Silva, Maria Irene A. G. Silva, Sônia P. Leite
The Croton heliotropiifolius Kunth species is used to treat stomach discomforts, vomiting, dysentery and as antipyretic. This work was developed in order to perform a phytochemical screening of the methanol extracts of the stem, flowers and leaves of the species C. heliotropiifolius, and evaluate toxicity on Artemia salina. The stem extracts, flowers and leaves showed yields of 22.7 %; 31.4 %; 14.2 %, respectively. The presence of chemical compounds such as flavonoids in leaves and flowers, coumarins stem and in lower concentrations in the flowers has been identified. Alkaloids and saponins are absent in the studied material. The methanol extracts showed high toxicity (CL50 values <80 µg / mL) to Artemia salina. This study may contribute to the deepening of knowledge of the chemical composition and toxicity of this species.
Outros
Rev. Virtual Quim. 2017
Um Compêndio de Inibidores de Tirosina Quinase: Fármacos Poderosos e Eficientes contra o Câncer
Dora Cristina S. Costa, Luana S. M. Forezi, Mariana Filomena C. Cardoso, Ruan Carlos B. Ribeiro, Angelo C. Pinto, Vitor F. Ferreira, Fernando de C. da Silva
The inhibitors of the enzymes tyrosine kinase (ITKs), also known by “tinibs”, have been used as the most modern and effective tools in the treatment of several types of cancer. Thihuge series of tyrosine kinase inhibitors, recently approved or under clinical trials, containing in each of them information such as: the first chemical synthesis, the mechanism of atrials stage and price in the market.
Quim. Nova 2017
O prêmio Nobel de química em 2016: máquinas moleculares
Karla S. Feu, Francisco F. de Assis, Siddavatam Nagendra e Ronaldo A. Pilli
The figure shows the laureated scientists awarded with the Nobel Prize in Chemistry 2016. Copyright: © Nobel Media AB 2016.
Rev. Virtual Quim. 2017
O Papel: Uma Breve Revisão Histórica, Descrição da Tecnologia Industrial de Produção e Experimentos para Obtenção de Folhas A
Maria Betânia d’Heni Teixeira, Robson Alves de Oliveira,Thérèse Hofmann Gatti, Paulo A. Z. Suarez
This work presents relevant aspects of history, chemistry and technology of paper. In addition, two processes were presented to obtain sheets of handmade paper from papyrus (Cyperus papyrus) stem and paina (Ceiba speciosa). In the case of paina, long cellulose fibers with characteristics suitable to produce hand made paper for inkjet printing were obtained.
J. Braz. Chem. Soc. 2017
Nuclear Magnetic Resonance (1.40 T) and Mid Infrared (FTIR-ATR) Associated with Chemometrics as Analytical Methods for the AnEster Yield Obtained by Esterification Reaction
Sara R. M. Kollar; Etelvino H. Novotny; Claudia J. do Nascimento; Paulo A. Z. Suarez
1H NMR (60 and 300 MHz) and FTIR-ATR associated with chemometrics were used to quantify esterification of fatty acids with methanol.
J. Braz. Chem. Soc. 2017
Liver Damage Induced by Succinylacetone: A Shared Redox Imbalance Mechanism between Tyrosinemia and Hepatic Porphyrias
Vanessa E. S. Cardoso; Fernando Dutra; Chrislaine O. Soares; Atecla N. L. Alves; Estela Bevilacqua; Sonia M. Gagioti; Carlos A. A. Penatti; Etelvino J. H. Bechara
Overproduction of ALA in SAME-treated rats impairs redox balance and mimics the liver mitochondrial damage long detected in liver biopsies of porphyric individuals.
Quim. Nova 2016
Gilbert lewis e o centenário da teoria de ligação por par de elétrons
Carlos A. L. Filgueiras
A distribuição dos elétrons nos vértices de um cubo, do lítio ao flúor, como foi descrita pela primeira vez no artigo de Lewis de 1916, The Atom and the Molecule.
J. Braz. Chem. Soc. 2017
Evaluating the Potential of Biodiesel Production through Microalgae Farming in Photobioreactor and High Rate Ponds from Waste
David M. M. Pinho; Renato S. Oliveira; Vitor M. L. dos Santos; Welington F. Marques; Angelo C. Pinto; Michelle J. C. Rezende; Paulo A. Z. Suarez
The article evaluates farming of Chlorella sp. in photobioreactor and sewage sludge as potential source of fatty material for biodiesel production.
Rev. Virtual Quim. 2016
Desenvolvimento e Sínteses da Flibanserina (Addyi®) – o “Viagra® Feminino”
José C. Barros, Bruno A. Cotrim
In 2015, the drug Addyi® (flibanserin) was launched, the first drug to treatment of Female Sexual Interest/Arousal Disorder (FSIAD). The present work is an overview of the drug development, mechanism of action, synthetic routes to the active principle and finally the controversial approval process.
J. Braz. Chem. Soc. 2017
Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles
Waldenice A. Morais; Benício de Barros Neto; Isabella M. F. Cavalcanti; Francisco H. Xavier Junior; Nereide S. Santos-Magalhães; Maria Aparecida M. Maciel
Coencapsulation of t-DCTN and t-DCTN:HP-β-CD into PCL and PLGA microspheres were developed using factorial design. Oral formulations of PLGA microparticles containing t-Dwere obtained to be applied in in vivo studies.
J. Braz. Chem. Soc. 2017
Chiral Bistacrine Analogues: Synthesis, Cholinesterase Inhibitory Activity and a Molecular Modeling Approach
João P. B. Lopes; Jessie S. da Costa; Marco A. Ceschi; Carlos A. S. Gonçalves; Eduardo L. Konrath; Ana L. M. Karl; Isabella A. Guedes; Laurent E. Dardenne
Chiral bis(7)-tacrine compounds were synthesized in yields ranging from 40 to 80%. Both enantiomeric series were found to be potent AChE and BuChE inhibitors in vitro, with IC50nM and from 30 to 140 nM, respectively.
J. Braz. Chem. Soc. 2017
Application of Full Factorial Design to Evaluate the Effect of Different Variables on the Stability of Biodiesel:Diesel Blends under Storage Conditions
Michelle J. C. Rezende; Daniella L. Vale; Paula F. Aguiar; Carlos A. S. Riehl; Debora A. Azevedo
The stability of biodiesel:diesel blends were studied in actual Brazilian storage conditions. The degradation was quantified by target compounds in the oxidation process and a full feffect of variables.
J. Braz. Chem. Soc. 2017
Anti-Trypanosoma Activity and Synergistic Effects of Natural and Semi-Synthetic Triterpenes and Predominant Cell Death through Amastigote Forms
Gleison D. P. Bossolani; Tânia Ueda-Nakamura; Sueli O. Silva; Benedito P. Dias Filho; Tulio O. G. Costa; Raúl H. R. Quintanilla; Sabrina T. Martinez; Valdir F. Veiga-Junior; Angelo C. Pinto and Celso V. Nakamura
Triterpenes showed promising activities and synergistic effects, which resulted in mitochondrial dysfunction and cell death by apoptosis, against amastigote forms of Trypanosoma cruzi
J. Braz. Chem. Soc. 10`7
An Investigation on Morphology and Fractal Dimension of Diesel and Diesel‑Biodiesel Soot Agglomerates
Aline L. N. Guarieiro; Arantzazu Eiguren-Fernandez; Gisele O. da Rocha; Jailson B. de Andrade
Fractal-like dimension and morphology of ultrafine particles emitted by a diesel engine run with B4, B50, and B100 are evaluated.
Síntese Orgânica
J. Braz. Chem. Soc. 2016
Ultrasound-Assisted Synthesis of Isatin-Type 5′-(4-Alkyl/Aryl-1H-1,2,3-triazoles) via 1,3-Dipolar Cycloaddition Reactions
Bianca N. M. Silva; Angelo C. Pinto; Fernando C. Silva; Vitor F. Ferreira; Bárbara V. Silva
5′-(4-Alkyl/aryl-1H-1,2,3-triazoles) was prepared under acidic conditions and ultrasound irradiation in just 5 minutes.
J. Braz. Chem. Soc. 2017
Synthesis of New Xanthenes Based on Lawsone and Coumarin via a Tandem Three‑Component Reaction
Mariana F. C. Cardoso; Luana S. M. Forezi; Victor G. S. Cavalcante; Cecília S. R. Juliani; Jackson Antônio L. C. Resende; David R. da Rocha; Fernando C. da Silva; Vitor F. Ferreira
The synthesis of several xanthenes based on the 1,3-dicarbonyl scaffolds lawsone and coumarin was developed using tandem three-component reactions involving the reagents ortbifunctional reagent, and an appropriate thiol. These reactions generated two series of para- and ortho-naphthoxanthenes that are structurally related to β- and β-pyranaphthocoumarin-xanthene derivatives.
J. Braz. Chem. Soc. 2017
Synthesis and Evaluation of Cytotoxic Effects of Amino-ester Derivatives of Natural α,β-Amyrin Mixture
Mauricio M. Victor; Jorge M. David; Marcelo A. S. dos Santos; André L. B. S. Barreiros; Marizeth L. Barreiros; Fernanda S. Andrade; Adriana A. Carvalho; Maria Claudia S. Luciano; ManW. A. Barros-Nepomuceno; Claudia Pessoa
Natural α,β-amyrin mixtures isolated from Esenbeckia grandiflora were transformed into aminoesters and their cytotoxic activities were evaluated against PC-3, HCT-116 and HL-60morpholine and imidazole derivatives showed moderate activity against HL60.
J. Braz. Chem. Soc. 2017
Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Activities
Sara L. S. Gomes; Gardenia C. G. Militão; Arinice M. Costa; Cláudia Ó. Pessoa; Letícia V. Costa-Lotufo; Edézio F. Cunha-Junior; Eduardo C. Torres-Santos; Paulo R. R. Costa; Alcides J. M. da Silva
Suzuki-Miyaura cross coupling reaction between 2-hydroxy-3-iodonaphthalene-1,4-dione and a series of arylboronic acids/esters followed by OH-protection as the correspondinreported. The synthesized compounds were evaluated regarding their antineoplastic and antileishmanial activities furnishing promising results.
Rev. Virtual Quim. 2017
Otimização da Síntese do Fluconazol: um Importante Fármaco Antifúngico da Classe dos Azóis
Cheyene A. C. Menozzi, Frederico S. Castelo-Branco, Rodolfo Rodrigo F. França, Jorge Luiz O. Domingos, Núbia Boechat
Fluconazole is an azolic second-generation antifungal drug and is part of the National List of Essential Drugs (RENAME) of the Brazilian Ministry of Health. It is considered as first choice for the treatment of some opportunistic fungal infections and also applied in the AIDS treatment program as prophylactic therapy to avoid these infections. Due to the importance of fluconazole for the Brazilian Health System (SUS), it is strategic the domain of its obtaining process. Thus, improvements in the synthesis of this substance are also of special interest. In this work, many changes were proposed and carried out in the original fluconazole synthetic route, aiming to increase yield and using solvents and processes with a lower environmental impact. With these optimizations, the overall yield achieved was 53%, which is about 10 times higher than that of the original process.
J. Braz. Chem. Soc. 2017
New Strategies for Molecular Diversification of 2-[Aminoalkyl-(1H-1,2,3-triazol-1-yl)]-1,4-naphthoquinones Using Click Chemistry
Ronaldo N. de Oliveira; Mauro G. da Silva; Moara Targino da Silva; Valentina N. Melo; Wagner O. Valença; Josinete Angela da Paz; Celso A. Camara
Click-chemistry protocol aims to access molecular diversity based on two strategies to obtain scaffolds of 2-amino-alkyl substituted natural and synthetic 1,4-naphthoquinoneheterocyclic ring.
J. Braz. Chem. Soc. 2017
Multi-gram Preparation of 7-Nitroquinoxalin-2-amine
Daniel N. do Amaral; Fernando R. de Sá Alves; Eliezer J. Barreiro; Stefan A. Laufer; Lídia M. Lima
A methodology to obtain 7-nitroquinoxalin-2-amine using o-phenylenediamine as starting material in a five-step procedure in good yields and high purity.
Rev. Virtual Quim. 2017
Métodos Sintéticos para a Preparação de Biarilas
Thais de B. da Silva, Fernando de C. da Silva, Vitor F. Ferreira
The biaryl structural unit is often found in natural products, drugs and agrochemicals. Therefore, the formation of the carbon-carbon bond is of extreme importance in the synthetic planning of substances. Many methods of obtaining biaryls are described in the literature, however, nickel or palladium catalyzed cross-coupling methodologies, such as Kuma-Tamao-Corriu, Negishi, Migita-Kosug-Stille, SuzukiMiyaura and Hiyama are the most important and most used tools today. These reactions avoid the need for protection and deprotection of functional groups, as they are tolerant to most groups, such as: aldehydes, ketones, amino, nitriles, hydroxides, esters and nitro group. In this work, these cross-coupling methodologies and their main characteristics will be discuss.
J. Braz. Chem. Soc. 2017
First Asymmetric Reduction of Isatin by Marine-Derived Fungi
Willian G. Birolli; Irlon M. Ferrreira; David E. Q. Jimenez; Bianca N. M. Silva; Bárbara V. Silva; Angelo C. Pinto; André L. M. Porto
A screening was carried out and several strains of marine-derived fungi were able to reduce isatin and produced the enantioenriched dioxindole, up to 66% ee and with different conversions (11-98%).
Quim. Nova 2016
Estratégias de síntese na descoberta de fármacos: o emprego da síntese orientada pela diversidade estrutural
Diego Pereira Sangi
This article shows the synthetic strategies used in drug discovery process, highlighting the principal approaches towards generating scaffold diversity in a Diversity-Oriented Synthes.
J. Braz. Chem. Soc. 2017
Eco-Friendly, Catalyst and Solvent-Free, Synthesis of Acetanilides and N-Benzothiazole-2-yl-acetamides
Silvio Cunha; Lourenço L. B. de Santana
An expeditious and green synthesis of acetamides is described in good yield without external heating, and with simple purification.
J. Braz. Chem. Soc. 2017
Cellulose Oxidation and the Use of Carboxyl Cellulose Metal Complexes in Heterogeneous Catalytic Systems to Promote Suzuki-Mand C−O Bond Formation Reaction
Guilherme B. C. Martins; Marcelo R. dos Santos; Marcus V. R. Rodrigues; Renata R. Sucupira; Luisa Meneghetti; Adriano L. Monteiro; Paulo A. Z. Suarez
Application of metal-modified cellulose as ligand in heterogeneous catalytic systems of coupling reactions as a new option for green and sustainable chemistry.
Rev. Virtual Quim. 2017
As Isatinas do Professor Angelo
Sabrina T. Martinez, Vitor F. Ferreira
The isatin is an attractive and versatile molecule. This should be the definition of isatin by Professor Angelo C. Pinto, a scientist with the soul of an artist who dedicated part of hisatin and used it as a starting material in several new reactions. This small molecule linked his ideas with many new methods in organic synthesis. The purpose of this paper is brilliant work on isatins and associated it with some of his passions.
Química de Produtos Naturais
Angelocunhol: New Erythroxylane Diterpene and Other Compounds from Simira sampaioana (Rubiaceae)
J. Braz. Chem. Soc.
Vinicius F. Moreira; Ivo J. C. Vieira; Raimundo Braz-Filho
A new erythroxylane diterpene, named angelocunhol, was characterized together with 14 known compounds from the Simira sampaioana (Rubiaceae) wood. This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.5935/0103-5053.20160158
Brazoides A-D, New Alkaloids from Justicia gendarussa Burm. F. Species
J. Braz. Chem. Soc.
Luciana G. S. Souza; Macia C. S. Almeida; Telma L. G. Lemos; Paulo R. V. Ribeiro; Kirley M. Canuto; Raimundo Braz-Filho; Catarina N. Del Cistia; Carlos Mauricio R. Sant’Anna; Francisco Moraes
Four new alkaloids, named Brazoides A-D, together with three known compounds were isolated from Justicia gendarussa Burm. F. (Acanthaceae). This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20160291
Composição química, atividade citotóxica e antioxidante de um tipo de própolis da Bahia#
Quim. Nova
Darlan C. dos Santos1,2; Jorge Mauricio David2,*; Juceni Pereira David3
Saturated hydrocarbons, methyl cinnamate, sitosterol cinnamate and ananixanthone were isolated from the brown propolis (classified as Propolis Type 6). The extracts showed toxic
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0100-4042.20160174
Cyclo-(trp-phe) diketopiperazines from the endophytic fungus Aspergillus versicolor isolated from Piper aduncum
Quim. Nova
Juliana R. Gubiani1; Helder L. Teles2; Geraldo H. Silva3; Maria Cláudia M. Young4; José O. Pereira5; Vanderlan S. Bolzani1; Angela R. Araujo1,*
An endophytic fungus A. versicolor isolated from the leaves of P. aduncum was used to produce six known compounds: three peptide derivatives, one adenine derivative, onebenzoic acid derivative.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0100-4042.20160165
Anti-hyperglycemic, antioxidant, and anti-inflammatory activities of extracts and metabolites from Sida acuta and Sida rhombifoli
Quim. Nova
Amira Arciniegas; Ana L. Pérez-Castorena*; Antonio Nieto-Camacho; Yuko Kita; Alfonso Romo de Vivar
The acetone extracts of S. acuta and S. rhombifolia inhibited yeast α-glucosidase (IC50 8.49 ± 0.66 and 8.10 ± 0.34 μg mL-1, respectively) and showed mild activity on DPPH and Tcompounds 5 was active in all evaluations.
http://dx.doi.org/10.21577/0100-4042.20160182
Química de Produtos Naturais: Plantas que Testemunham Histórias
Rev. Virtual Qui
Márcia R. Almeida, Sabrina T. Martinez, Angelo C. Pinto
The botanical description of plants, classifi cation and use of some of them as medicine to treat typical diseases of Brazilian regions may be accompanied by reports described in hisexpeditions of adventurers and research of physicians and pharmacists. These were primarily responsible for discoveries that are still remembered and rethought for the developmthese plants. This work presents a list of plants and their applications and uses by diff erent people with the evolution of history.
http://dx.doi.org/10.21577/1984-6835.20170068
Chemical Constituents of Psychotria nemorosa Gardner and Antinociceptive Activity
Braz. Chem.
Nivea O. Calixto; Millena S. Cordeiro; Thais B. S. Giorno; Gibson G. Oliveira; Norberto P. Lopes; Patricia D. Fernandes; Angelo C. Pinto; Claudia M. Rezende
This is the fi rst phytochemical sudy of Psychotria nemorosa Gardner leaves (Rubiaceae) established in a metabolomic perspective by GC-MS and LC-MS, besides its antinociceptive ac
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20160219
The Chemistry of the Sesquiterpene Alkaloids
Braz. Chem.
Timothy J. Brocksom; Kleber T. de Oliveira; André L. Desiderá
This review presents the structures, biological activities, biosynthesis, and syntheses of the sesquiterpene alkaloids, principally the dendrobine and guaipyridine groups.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170049
Triterpenoides, fenólicos e efeito fitotóxico das folhas de Eugenia flavescens DC (Myrtaceae)
Quim. Nova
Antonio J. Cantanhede Filho1,*,#; Lourivaldo S. Santos1; Giselle M. S. P. Guilhon1; Maria das Graças B. Zoghbi2; Pollyane S. Ports3; Iris C. S. Rodrigues2
This article reports the chemical study, LC/MS phenolic profile and phytotoxic effect from Eugenia flavescens, a plant native to Northern Brazil.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0100-4042.20160190
HS-SPME as an efficient tool for discriminating chemotypes of Lippia alba (Mill.) N. E. Brown
Quim. Nova
Aiêrta C. C. da SilvaI; Francisco G. BarbosaI,*; Jair MafezoliI; Maria da C. F. de OliveiraI; Terezinha F. de OliveiraII
HS-SPME was used to distinguish three chemotypes of Lippia alba and compared with the traditional hydrodistillation method.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0100-4042.20160156
Copaiba Oil and Its Constituent Copalic Acid as Chemotherapeutic Agents against Dermatophytes
Braz. C
Marcela T. Nakamura; Eliana H. Endo; João Paulo B. de Sousa; Daniel R. Callejon; Tânia Ueda-Nakamura; Benedito P. Dias Filho; Osvaldo de Freitas; Celso V. Nakamura; Norberto P.
Copalic acid activity against dermatophytes Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum gypseum.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20160309
One strain-many compounds (OSMAC) method for production of phenolic compounds using Camarops sp., an endophytic fungusmacrophylla (Rubiaceae)
Quim. Nova
Juliana R. GubianiI; Thomas R. HabeckI; Vanessa M. ChaplaII; Geraldo H. SilvaIII; Vanderlan S. BolzaniI; Angela R. AraujoI,*
Endophytic fungus Camarops sp. isolated from the leaves of Alibertia macrophylla, was used to produce seven phenolic derivatives through the one strain-many compounds (OSMby 2D NMR and HRESIMS spectra.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0100-4042.20160169
Constituintes químicos e atividade antioxidante in vivo de flavonoides isolados de Clusia lanceolata (Clusiaceae)
Quim. Nova
Rafaela O. FerreiraI,*; Almir R. de Carvalho JuniorI; Cristiano J. RigerI; Rosane N. CastroI; Tania M. S. da SilvaII; Mário G. de CarvalhoI
Flavonoid C-glycosides and phaeophytins from Clusia lanceolata. Vitexin derivatives with in vivo antioxidant activity.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0100-4042.20160131
Comparação entre a composição química e capacidade antioxidante de diferentes extratos de própolis verde
Quim. Nova
Fernanda B. Salgueiro; Rosane N. Castro*
A multivariate analysis of chemical composition of commercial and in natura Brazilian green propolis.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0100-4042.20160136
Validação de Métodos por CG-EM para Análise de Carvacrol e trans-β-Cariofileno em Amostras Comerciais Contendo Óleos Essenciais
Rev. Virtual Q
Francisco Carlos de Oliveira, André Luiz M. Camelo, Francisco Felipe M. da Silva, Francisco Thiago C. de Souza, Elisane Longhinotti, Francisco Geraldo Barbosa, Ronaldo F. Nascimento
Carvacrol and trans-β-caryophyllene are widely found several medicinal plants, being assigned to these compounds various pharmacological properties. Therefore, this work presthese compounds in the species of Lippia sidoides and Rosmarinus officinalis and a copaiba oil sample available in popular trade in Fortaleza. Thus, essential oil samples were dchromatograph with mass spectrometric detector (GC-MS). Validation parameters showed satisfactory values, such as linearity, lower limit of detection and quantitation, reproduciday) considerable analysis and recovery values. Of the compounds studied, the Lippia sidoides species presented a percentage of 32.01 of carvacrol and 1.78 of trans-β-caryoofficinales found a percentage of 0.28 and 0.34 respectively for carvacrol and trans-β-caryophyllene. For oil copaiba not logged carvacrol, however, the trans-β-caryophyllene, was With the results, the method can be considered as a useful analytical tool for quality control of trans-β-caryophyllene and carvacrol and the derivatives in the essential oils.
http://dx.doi.org/10.21577/1984-6835.20170059
Screening Fitoquímico e Avaliação da Toxicidade de Croton heliotropiifolius Kunth (Euphorbiacea) frente à Artemia salina Leach
Rev. Virtual Q
Jéssica A. G. Silva, Izabela R. Lima, Marllon Alex N. Santana, Tainá Maria S. da Silva, Maria Irene A. G. Silva, Sônia P. Leite
The Croton heliotropiifolius Kunth species is used to treat stomach discomforts, vomiting, dysentery and as antipyretic. This work was developed in order to perform a phytochemicextracts of the stem, flowers and leaves of the species C. heliotropiifolius, and evaluate toxicity on Artemia salina. The stem extracts, flowers and leaves showed yields of 22.7 %; 31.4presence of chemical compounds such as flavonoids in leaves and flowers, coumarins stem and in lower concentrations in the flowers has been identified. Alkaloids and saponimaterial. The methanol extracts showed high toxicity (CL50 values <80 μg / mL) to Artemia salina. This study may contribute to the deepening of knowledge of the chemical comspecies.
http://dx.doi.org/10.21577/1984-6835.20170060
Óleo Essencial das Flores de Eugenia klotzschiana (Myrtaceae): Composição Química e Atividades Tripanocida e Citotóxica In Vitro
Rev. Virtual Qui
Nárgella S. Carneiro, José Milton Alves, Cassia Cristina F. Alves, Viviane R. Esperandim, Mayker Lazaro D. Miranda
Chagas disease, which is caused by Trypanosoma cruzi, has been commonly treated by nifurtimox and benzonidazole, two drugs that cause several side effects. As a result, thetreating neglected diseases has increased in recent years and plants have become a promising alternative to developing new medicines. Therefore, this study aimed to determine the essential oil from fresh flowers of Eugenia klotzchiana and to evaluate for the first time its trypanocidal and cytotoxic potential in vitro. The essential oil from the frehydrodistillation carried out by a Clevenger apparatus and its chemical composition was determined by GC-MS. The main compounds found in the essential oil were sesƋuiteƌpeŶobicyclogermacrene (10.2%) and spathulenol (20.9%). Results showed that the essential oil had strong trypanocidal activity against the trypomastigote forms of Trypanosoma crŵodeƌate ĐLJtotodžiĐitLJ agaiŶst fiďƌoďlasts iŶ the ĐoŶĐeŶtƌatioŶ ƌaŶge ;CC50 = ϮϮϬ.ϯ μg/ŵLͿ. IŶ shoƌt, the essential oil from fresh flowers of Eugenia klotzchiana can be considercompounds for the development of antiparasitic drugs.
http://dx.doi.org/10.21577/1984-6835.20170080
Flavonoides e Atividade Antioxidante das Folhas de Bauhinia longifolia (Bong.) Steud.
Rev. Virtual Qui
Alda Ernestina dos Santos, Cleber B. Barreto Junior, Ricardo M. Kuster
In this study the chemical composition of Bauhinia longifolia leaves was evaluated. The phytochemical study of the methanolic extract from the leaves of B. longifolia led to elucidation of aglycone quercetin and its 3-O-monoglycoside derivatives: quercetin-3-O-α-arabinofuranoside, quercetin-3-O-α- rhamnopyranoside, quercetin-3-O-β-glucopyrangalactopyranoside. Flavonoid structures were determined using a combination of techniques, including HPLC-UV, ESI-MS and NMR, in addition to the literature data. The antioxdichloromethane, ethyl acetate (EtOAc) and butanol (BuOH) fractions from the partition of the methanolic extract from the leaves of B. longifolia was evaluated by the DPPH raexpressed in terms of its CE50. The highest antioxidant activity was observed for EtOAc fractions (CE50 = Ϯϭ.Ϯ μg/ŵLͿ aŶd BuOH ;CE50 = ϭϲ.ϭ μg /ŵLͿ fractions. They were also evaluby the Folin-Ciocalteau spectrophotometric method, which revealed high ĐoŶĐeŶtratioŶs of pheŶoliĐ ĐoŵpouŶds iŶ EtOAĐ ;ϯϵϯ.ϴ μg EAG/ŵgͿ aŶd BuOH ;ϰϮϮ.ϰ μg EAG/mg) and lohexaŶe ;Ϯϯ.ϴ μg EAG/ŵgͿ aŶd diĐhloroŵethaŶe ;ϲϭ.ϵ μg EAG / ŵgͿ fraĐtioŶs. For the first tiŵe the antioxidant activity of B. longifolia leaves is reported, as well as the presence of thhyperin and isoquercitrin, flavonoid commun on Bauhinia genus, but never described for B. longifolia. Thus the present study contributes with the chemical and pharmacological great medicinal importance specie.
http://dx.doi.org/10.21577/1984-6835.20170076
Óleos Essenciais dos Frutos e Folhas de Kielmeyera coriacea: Atividade Antitumoral e Estudo Químico
Rev. Virtual Qui
Raiane S. Lemes, Géssica Carla S. Costa, Douglas Carlos S. Silva, Amanda B. Becceneri, Keylla U. Bicalho, Mayker Lazaro D. Miranda, Vania S. S. Diniz, Cristiane M. Cazal
Kielmeyera coriacea, a typical tree species of the Cerrado (Brazilian Savanna), popularly known as “pausanto” and it is used in traditional medicine for the treatment of various dchemically characterize the essential oils of leaves and fruits of K. coriacea and to evaluate its antitumor activity against human tumor cell lines MDA-MB-231 (breast tumor) and Dway to search for new drugs derived from natural sources. Essential oils were extracted by hydrodistillation in Clevenger. The average yield of essential oil of leaves and frurespectively. In leaves from K. coriacea, the major compounds found in the essential oils, were geranyl linalool (27,78), 2- Acetate (2E) Tridecenol (9.06%), E-nerolidol (7.70%) and compounds found in essential oils of fruits were D-germacrene (18.94%), neointermedeol (12.18%), bicyclogermacrene (12.00%), Viridiflorol (9,30 %), Globulol (8,76%), Epi-α-muu(5,00%).. The essential oils of fruits inhibited the proliferation of tumor cell lines DU-145 and MDAMB-231, as well as of the non-tumor cells (FH -Human fibroblasts). By contrast thenot active in any tested tumor lineage. To our knowledge, this is the first report on the chemical composition and antitumor activity of this species, and it clearly enhance our chemic
http://dx.doi.org/10.21577/1984-6835.20170073
Síntese Orgânica
As Isatinas do Professor Angelo
Rev. Virtual Qui
Sabrina T. Martinez, Vitor F. Ferreira
The isatin is an attractive and versatile molecule. This should be the definition of isatin by Professor Angelo C. Pinto, a scientist with the soul of an artist who dedicated part of hisatin and used it as a starting material in several new reactions. This small molecule linked his ideas with many new methods in organic synthesis. The purpose of this paper is brilliant work on isatins and associated it with some of his passions.
http://dx.doi.org/10.21577/1984-6835.20170069
Ultrasound-Assisted Synthesis of Isatin-Type 5′-(4-Alkyl/Aryl-1H-1,2,3-triazoles) via 1,3-Dipolar Cycloaddition Reactions
Braz. Chem. Soc
Bianca N. M. Silva; Angelo C. Pinto; Fernando C. Silva; Vitor F. Ferreira; Bárbara V. Silva
5′-(4-Alkyl/aryl-1H-1,2,3-triazoles) was prepared under acidic conditions and ultrasound irradiation in just 5 minutes.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.5935/0103-5053.20160121
First Asymmetric Reduction of Isatin by Marine-Derived Fungi
Braz. Chem. So
Willian G. Birolli; Irlon M. Ferrreira; David E. Q. Jimenez; Bianca N. M. Silva; Bárbara V. Silva; Angelo C. Pinto; André L. M. Porto
A screening was carried out and several strains of marine-derived fungi were able to reduce isatin and produced the enantioenriched dioxindole, up to 66% ee and with different con
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20160256
New Strategies for Molecular Diversification of 2-[Aminoalkyl-(1H-1,2,3-triazol-1-yl)]-1,4-naphthoquinones Using Click Chemistry
Braz. Chem.
Ronaldo N. de Oliveira; Mauro G. da Silva; Moara Targino da Silva; Valentina N. Melo; Wagner O. Valença; Josinete Angela da Paz; Celso A. Camara
Click-chemistry protocol aims to access molecular diversity based on two strategies to obtain scaffolds of 2-amino-alkyl substituted natural and synthetic 1,4-naphthoquinoneheterocyclic ring.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
Estratégias de síntese na descoberta de fármacos: o emprego da síntese orientada pela diversidade estrutural
Quim. No
Diego Pereira Sangi*
This article shows the synthetic strategies used in drug discovery process, highlighting the principal approaches towards generating scaffold diversity in a Diversity-Oriented Synthes
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.5935/0100-4042.20160089
Métodos Sintéticos para a Preparação de Biarilas
Rev. Virtual Qui
Thais de B. da Silva, Fernando de C. da Silva, Vitor F. Ferreira
The biaryl structural unit is often found in natural products, drugs and agrochemicals. Therefore, the formation of the carbon-carbon bond is of extreme importance in the synthMany methods of obtaining biaryls are described in the literature, however, nickel or palladium catalyzed cross-coupling methodologies, such as Kuma-Tamao-Corriu, Negishi, Migitaand Hiyama are the most important and most used tools today. These reactions avoid the need for protection and deprotection of functional groups, as they are tolerant to mostketones, amino, nitriles, hydroxides, esters and nitro group. In this work,
http://dx.doi.org/10.21577/1984-6835.20170074
Otimização da Síntese do Fluconazol: um Importante Fármaco Antifúngico da Classe dos Azóis
Rev. Virtual Qui
Cheyene A. C. Menozzi, Frederico S. Castelo-Branco, Rodolfo Rodrigo F. França, Jorge Luiz O. Domingos, Núbia Boechat
Fluconazole is an azolic second-generation antifungal drug and is part of the National List of Essential Drugs (RENAME) of the Brazilian Ministry of Health. It is considered as firstsome opportunistic fungal infections and also applied in the AIDS treatment program as prophylactic therapy to avoid these infections. Due to the importance of fluconazole for(SUS), it is strategic the domain of its obtaining process. Thus, improvements in the synthesis of this substance are also of special interest. In this work, many changes were proporiginal fluconazole synthetic route, aiming to increase yield and using solvents and processes with a lower environmental impact. With these optimizations, the overall yield achie10 times higher than that of the original process.
http://dx.doi.org/10.21577/1984-6835.20170071
Synthesis of New Xanthenes Based on Lawsone and Coumarin via a Tandem Three‑Component Reaction
Mariana F. C. Cardoso; Luana S. M. Forezi; Victor G. S. Cavalcante; Cecília S. R. Juliani; Jackson Antônio L. C. Resende; David R. da Rocha; Fernando C. da Silva; Vitor F. Ferreira
The synthesis of several xanthenes based on the 1,3-dicarbonyl scaffolds lawsone and coumarin was developed using tandem three-component reactions involving the reagents ortbifunctional reagent, and an appropriate thiol. These reactions generated two series of para- and ortho-naphthoxanthenes that are structurally related to β- and β-pyranaphthocoumarin-xanthene derivatives.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170032
Eco-Friendly, Catalyst and Solvent-Free, Synthesis of Acetanilides and N-Benzothiazole-2-yl-acetamides
Braz. Chem. So
Silvio Cunha; Lourenço L. B. de Santana
An expeditious and green synthesis of acetamides is described in good yield without external heating, and with simple purification.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20160265
Multi-gram Preparation of 7-Nitroquinoxalin-2-amine
Daniel N. do Amaral; Fernando R. de Sá Alves; Eliezer J. Barreiro; Stefan A. Laufer; Lídia M. Lima
A methodology to obtain 7-nitroquinoxalin-2-amine using o-phenylenediamine as starting material in a five-step procedure in good yields and high purity.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170018
Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Activities
Sara L. S. Gomes; Gardenia C. G. Militão; Arinice M. Costa; Cláudia Ó. Pessoa; Letícia V. Costa-Lotufo; Edézio F. Cunha-Junior; Eduardo C. Torres-Santos; Paulo R. R. Costa; Alcides J. M
Suzuki-Miyaura cross coupling reaction between 2-hydroxy-3-iodonaphthalene-1,4-dione and a series of arylboronic acids/esters followed by OH-protection as the correspondinreported. The synthesized compounds were evaluated regarding their antineoplastic and antileishmanial activities furnishing promising results.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20160326
Cellulose Oxidation and the Use of Carboxyl Cellulose Metal Complexes in Heterogeneous Catalytic Systems to Promote Suzuki-Mand C−O Bond Formation Reaction
Guilherme B. C. Martins; Marcelo R. dos Santos; Marcus V. R. Rodrigues; Renata R. Sucupira; Luisa Meneghetti; Adriano L. Monteiro; Paulo A. Z. Suarez
Application of metal-modified cellulose as ligand in heterogeneous catalytic systems of coupling reactions as a new option for green and sustainable chemistry.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170051
Synthesis and Evaluation of Cytotoxic Effects of Amino-ester Derivatives of Natural α,β-Amyrin Mixture
Mauricio M. Victor; Jorge M. David; Marcelo A. S. dos Santos; André L. B. S. Barreiros; Marizeth L. Barreiros; Fernanda S. Andrade; Adriana A. Carvalho; Maria Claudia S. Luciano; ManW. A. Barros-Nepomuceno; Claudia Pessoa
Natural α,β-amyrin mixtures isolated from Esenbeckia grandiflora were transformed into aminoesters and their cytotoxic activities were evaluated against PC-3, HCT-116 and HL-60morpholine and imidazole derivatives showed moderate activity against HL60.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170064
Outros
Liver Damage Induced by Succinylacetone: A Shared Redox Imbalance Mechanism between Tyrosinemia and Hepatic Porphyrias
Braz. Chem. So
Vanessa E. S. Cardoso; Fernando Dutra; Chrislaine O. Soares; Atecla N. L. Alves; Estela Bevilacqua; Sonia M. Gagioti; Carlos A. A. Penatti; Etelvino J. H. Bechara
Overproduction of ALA in SAME-treated rats impairs redox balance and mimics the liver mitochondrial damage long detected in liver biopsies of porphyric individuals.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20160294
An Investigation on Morphology and Fractal Dimension of Diesel and Diesel‑Biodiesel Soot Agglomerates
Aline L. N. Guarieiro; Arantzazu Eiguren-Fernandez; Gisele O. da Rocha; Jailson B. de Andrade
Fractal-like dimension and morphology of ultrafine particles emitted by a diesel engine run with B4, B50, and B100 are evaluated.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20160306
Nuclear Magnetic Resonance (1.40 T) and Mid Infrared (FTIR-ATR) Associated with Chemometrics as Analytical Methods for the AnEster Yield Obtained by Esterification Reaction
Sara R. M. Kollar; Etelvino H. Novotny; Claudia J. do Nascimento; Paulo A. Z. Suarez
1H NMR (60 and 300 MHz) and FTIR-ATR associated with chemometrics were used to quantify esterification of fatty acids with methanol.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170031
Application of Full Factorial Design to Evaluate the Effect of Different Variables on the Stability of Biodiesel:Diesel Blends under St
Michelle J. C. Rezende; Daniella L. Vale; Paula F. Aguiar; Carlos A. S. Riehl; Debora A. Azevedo
The stability of biodiesel:diesel blends were studied in actual Brazilian storage conditions. The degradation was quantified by target compounds in the oxidation process and a full feffect of variables.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170041
Evaluating the Potential of Biodiesel Production through Microalgae Farming in Photobioreactor and High Rate Ponds from Waste
David M. M. Pinho; Renato S. Oliveira; Vitor M. L. dos Santos; Welington F. Marques; Angelo C. Pinto; Michelle J. C. Rezende; Paulo A. Z. Suarez
The article evaluates farming of Chlorella sp. in photobioreactor and sewage sludge as potential source of fatty material for biodiesel production.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170097
Chiral Bistacrine Analogues: Synthesis, Cholinesterase Inhibitory Activity and a Molecular Modeling Approach
João P. B. Lopes; Jessie S. da Costa; Marco A. Ceschi; Carlos A. S. Gonçalves; Eduardo L. Konrath; Ana L. M. Karl; Isabella A. Guedes; Laurent E. Dardenne
Chiral bis(7)-tacrine compounds were synthesized in yields ranging from 40 to 80%. Both enantiomeric series were found to be potent AChE and BuChE inhibitors in vitro, with IC50nM and from 30 to 140 nM, respectively.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170074
Coencapsulation of trans-Dehydrocrotonin and trans
Waldenice A. Morais; Benício de Barros Neto; Isabella M. F. Cavalcanti; Francisco H. Xavier Junior; Nereide S. Santos-Magalhães; MMaciel
Coencapsulation of t-DCTN and t-DCTN:HP-β-CD into PCL and PLGA microspheres were developed using factorial design. Oral formulations of PLGA microparticles containing t-Dwere obtained to be applied in in vivo studies.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20160331
Anti-Trypanosoma Activity and Synergistic Effects of Natural and Semi-Synthetic Triterpenes and Predominant Cell Death throughAmastigote Forms
Gleison D. P. Bossolani; Tânia Ueda-Nakamura; Sueli O. Silva; Benedito P. Dias Filho; Tulio O. G. Costa; Raúl H. R. Quintanilla; Sabrina T. Martinez; Valdir F. Veiga-Junior; Angelo C. Pin
Triterpenes showed promising activities and synergistic effects, which resulted in mitochondrial dysfunction and cell death by apoptosis, against amastigote forms of Trypanosoma c
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0103-5053.20170103
O prêmio Nobel de química em 2016: máquinas moleculares#
Quim. N
Karla S. FeuI,*; Francisco F. de AssisI; Siddavatam NagendraI,II; Ronaldo A. PilliI
The figure shows the laureated scientists awarded with the Nobel Prize in Chemistry 2016. Copyright: © Nobel Media AB 2016.
http://dx.doi.org/10.21577/0100-4042.20170001
Gilbert lewis e o centenário da teoria de ligação por par de elétrons#
Quim. Nova
Carlos A. L. Filgueiras
A distribuição dos elétrons nos vértices de um cubo, do lítio ao flúor, como foi descrita pela primeira vez no artigo de Lewis de 1916, The Atom and the Molecule.
This paper is part of the PubliSBQ Special Issue in honor of the late Prof Angelo da Cunha Pinto.
http://dx.doi.org/10.21577/0100-4042.20160171
Desenvolvimento e Sínteses da Flibanserina (Addyi®) – o “Viagra® Feminimo”
Rev. Virtual Q
José C. Barros, Bruno A. Cotrim
In 2015, the drug Addyi® (flibanserin) was launched, the first drug to treatment of Female Sexual Interest/Arousal Disorder (FSIAD). The present work is an overview of the drug action, synthetic routes to the active principle and finally the controversial approval process
http://dx.doi.org/10.5935/1984-6835.20160069
Um Compêndio de Inibidores de Tirosina Quinase: Fármacos Poderosos e Eficientes contra o Câncer
Rev. Virtual Qu
Dora Cristina S. Costa, Luana S. M. Forezi, Mariana Filomena C. Cardoso, Ruan Carlos B. Ribeiro, Angelo C. Pinto, Vitor F. Ferreira, Fernando de C. da Silva
The inhibitors of the enzymes tyrosine kinase (ITKs), also known by “tinibs”, have been used as the most modern and effective tools in the treatment of several types of cancer. Thihuge series of tyrosine kinase inhibitors, recently approved or under clinical trials, containing in each of them information such as: the first chemical synthesis, the mechanism of atrials stage and price in the market.
http://dx.doi.org/10.21577/1984-6835.20170063
O Papel: Uma Breve Revisão Histórica, Descrição da Tecnologia Industrial de Produção e Experimentos para Obtenção de Folhas A
Rev. Virtual Qui
Maria Betânia d’Heni Teixeira, Robson Alves de Oliveira,Thérèse Hofmann Gatti, Paulo A. Z. Suarez
This work presents relevant aspects of history, chemistry and technology of paper. In addition, two processes were presented to obtain sheets of handmade paper from papyrus paina (Ceiba speciosa). In the case of paina, long cellulose fibers with characteristics suitable to produce hand made paper for inkjet printing were obtained.
Coleção Especial da PubliSBQ - IUPAC 2017
Esta coleção virtual reúne artigos publicados nos periódicos da Sociedade Brasileira de Química (SBQ), apresentados durante o Congresso da IUPAC 2017, em São Paulo.
Com trabalhos de grande relevância científica, a seleção inclui publicações do Journal of the Brazilian Chemical Society (JBCS) e da Química Nova. A coleção destaca os avanços em diversas áreas da Química e oferece uma valiosa fonte de referência para pesquisadores, professores e estudantes.
Analytical & Food Chemistry
J. Braz. Chem. Soc. 2017
Flow Analysis: Looking Back and Forward
Fábio R. P. Rocha
Main characteristics and perspectives of the researches on flow analysis.
J. Braz. Chem. Soc. 2018
Determination of Target Pesticide Residues in Tropical Fruits EmployingMatrix Solid-Phase Dispersion (MSPD) Extraction Followed by High Resolution Gas Chromatography
Silvia S. Freitas; Felipe A. T. Serafim; Fernando M. Lanças
Pesticides are undesirable contaminants often present in food samples, particularly in fruits. A preliminary step (extraction) is conducted to transfer the pesticides from the originmatrix solid-phase dispersion (MSPD) was used) to a chromatographic system (in this paper gas chromatography with electron-capture detection (GC-ECD) was used) in ordcompounds.
J. Braz. Chem. Soc. 2018
In situ Determination of K, Ca, S and Si in Fresh Sugar Cane Leaves by Handheld Energy Dispersive X-Ray Fluorescence Spectrome
Marcelo B. B. Guerra; Andressa Adame; Eduardo de Almeida; Marcos A. S. Brasil; Carlos E. G. R. Schaefer; Francisco J. Krug
Portable energy dispersive X-ray fluorescence spectrometry was evaluated in the in situ analysis of fresh sugar cane leaves aiming at real time plant nutrition diagnosis.
Chemical Synthesis
J. Braz. Chem. Soc. 2018
Computer-Guided Total Synthesis of Natural Products. Recent Examples and Future Perspectives
Franco Della-Felice; Ronaldo A. Pilli; Ariel M. Sarotti
The use of nuclear magnetic resonance (NMR) calculations can facilitate the total synthesis of natural products of uncertain structural assignment.
Chemistry Education
Quim. Nova 2018
RELAÇÕES PEDAGÓGICAS EM AULAS DE CIÊNCIAS DA EDUCAÇÃO SUPERIOR
Ana Luiza de Quadros; Ariane Suelen Freitas Silva; Eduardo Fleury Mortimer
This figure illustrates a pedagogical link-making in the context of teaching and learning scientific conceptual knowledge.
Quim. Nova 2018
PHENOMENOLOGICAL APPROACHES TO STUDY LEARNING IN THE TERTIARY LEVEL CHEMISTRY LABORATORY
Santiago Sandi-Urena
Phenomenological studies allow a thorough description of laboratory learning environments. Through its analysis researchers gather a better understanding of how learning in thinforms pedagogical decisions and the design of curricular reforms.
Energy, Water and Environmental Sciences
J. Braz. Chem. Soc. 2018
Grafting of Quinones on Carbons as Active Electrode Materials in Electrochemical Capacitors
Thierry Brousse; Charles Cougnon; Daniel Bélanger
Grafting quinone molecules on porous carbons improves their charge storage properties for application as electrode in energy storage systems.
J. Braz. Chem. Soc. 2018
Fundamental Consideration for Electrochemical Engineering of Supercapattery
Bamidele Akinwolemiwa; George Z. Chen
Supercapattery is a generic term for a large number of hybrid electrochemical energy storage devices that combine the merits of supercapacitor and rechargeable battery. imperative to understand the charge storage mechanisms in the electrodes so that high voltage and space-material efficient stack of multiple cells can be manufactured witcommercial affordability.
J. Braz. Chem. Soc. 2018
Electrochemical Systems for Renewable Energy Conversion from Salinity and Proton Gradients
William G. Morais; Gilberto Lima; Wellington J. A. S. Gomes; Fritz Huguenin
Working principle and electrode materials of electrochemical systems for energy conversion from proton and salt gradient.
J. Braz. Chem. Soc. 2018
CO Tolerance and Stability of Proton Exchange Membrane Fuel Cells with Nafion® and Aquivion® Membranes and Mo‑Based Anode Electrocatalysts
Renato C. Iezzi; Rapher D. M. Santos; Gabriel C. da Silva; Valdecir A. Paganin; Edson A. Ticianelli
Cell performance decay after catalyst accelerated aging cyclings: unchanged Pt particles in the anode.
J. Braz. Chem. Soc. 2018
Advances of Submarine Groundwater Discharge Studies in South America
Mariele Paiva; Felipe H. Niencheski
Submarine groundwater discharge plays an important role on the biogeochemistry of the oceans. How much do we know about this process in South America?
Green Chemistry and Biotechnology
J. Braz. Chem. Soc. 2018
Simultaneous Multienzymatic Screening with Fluorogenic Probes
Maria L. S. O. Lima; Michel R. B. Chaves; Renato M. C. do Nascimento; Caroline C. S. Gonçalves; Anita J. Marsaioli
Multienzymatic screening is an interesting and promising methodology that makes possible the simultaneous monitoring of two or more enzymatic activities, in the same microprobes with different emission wavelengths.
J. Braz. Chem. Soc. 2018
Production of Furan Compounds from Sugarcane Bagasse Using a Catalytic System Containing ZnCl2/HCl or AlCl3/HCl in a Biphasic System
Gustavo R. Gomes; Daniel S. Rampon; Luiz P. Ramos
Cellulosic materials and sugarcane bagasse polysaccharides were converted to furan compounds using ZnCl2/HCl or AlCl3/HCl in a biphasic system.
J. Braz. Chem. Soc. 2018
Determination of Enantioselectivities by Means of Chiral Stationary Phase HPLC in Order to Identify Effective Proline-Derived Organocatalysts
Jorge Vargas-Caporali; Eusebio Juaristi
Chiral HPLC (high performance liquid chromatography) constitutes a central part in the evaluation of the organocatalytic potential of new ligands in prototypical asymmetric reaccorrelates in a wordplay a high ee (enantiomeric excess) chromatogram with a good Cat* (catalyst) and a racemic chromatogram with an unsatisfactory Cat*.
Inorganic and Structural Chemistry
J. Braz. Chem. Soc. 2018
Green Processing of Strategic Elements Based on Magnetic Nanohydrometallurgy
Ulisses Condomitti; Sabrina N. Almeida; Alceu T. Silveira Jr.; Fernando M. de Melo; Henrique E. Toma
Separation of strategic elements based on magnetic nanohydrometallurgy.
Macromolecules and Materials
J. Braz. Chem. Soc. 2018
Functionalization of P3HT with Various Mono- and Multidentate Anchor Groups
Florian Menk; Ana Fokina; Bernd Oschmann; Tobias A. Bauer; Yannick Nyquist; Lydia Braun; Jonathan Kiehl; Rudolf Zentel
To functionalize inorganic nanoparticles (TiO2 and CdSe) P3HT was synthesized and modified with various mono- and multidentate anchor groups via “click”-reaction.
Medicinal Chemistry and Chemical Biology
J. Braz. Chem. Soc. 2018
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator
Anna C. Silva; Hanae Benelkebir; Rosangela S. C. Lopes; Claudio C. Lopes; A. Ganesan
The total synthesis of the Sirtuin1 activator altissimacoumarin D was accomplished in six steps from 2,4-dihydroxybenzaldehyde.
J. Braz. Chem. Soc. 2018
Ditryptophan Cross-Links as Novel Products of Protein Oxidation
Verônica Paviani; Gabriel T. Galdino; Janaina N. dos Prazeres; Raphael F. Queiroz; Ohara Augusto
The formation of ditryptophan cross-links during the oxidation of proteins by biological agents and/or environmental factors is becoming recognized and deserves the attention of more researchers.
J. Braz. Chem. Soc. 2018
Development of Web and Mobile Applications for Chemical Toxicity Prediction
Vinicius M. Alves; Rodolpho C. Braga; Eugene Muratov; Carolina H. Andrade
General workfl ow for the development and implementation of quantitative structure-activity relationships (QSAR) models in web and mobile applications.
Nano Science and Technology
J. Braz. Chem. Soc. 2018
Nanopharmaceuticals and Their Applications in Bladder Cancer Therapy: a Mini Review
Nelson Durán; Wagner J. Fávaro
Graphene oxide (GO) and a nanostructured lipid carrier (NLC) carrying doxorubicin (DOX) were effective on
in vivo treatment of non-muscle invasive bladder cancer (NMIBC) witsilencing oncogenes via small interfering RNA (siRNA).
J. Braz. Chem. Soc. 2018
Electrodeposition of Prussian Blue/Carbon Nanotube Composites at a Liquid‑Liquid Interface
Samantha Husmann; Samuel G. Booth; Aldo J. G. Zarbin; Robert A. W. Dryfe
Prussian Blue electrodeposition over a carbon nanotube film assembled at a liquid-liquid interface has been monitored by in situ Raman spectroscopy.
Analytical & Food Chemistry
Flow Analysis: Looking Back and Forward
Braz. Chem. So
Fábio R. P. Rocha
Main characteristics and perspectives of the researches on flow analysis.
http://dx.doi.org/10.21577/0103-5053.20180018
In situ Determination of K, Ca, S and Si in Fresh Sugar Cane Leaves by Handheld Energy Dispersive X-Ray Fluorescence Spectrome
- Braz. Chem. So
Marcelo B. B. Guerra; Andressa Adame; Eduardo de Almeida; Marcos A. S. Brasil; Carlos E. G. R. Schaefer; Francisco J. Krug
Portable energy dispersive X-ray fluorescence spectrometry was evaluated in the in situ analysis of fresh sugar cane leaves aiming at real time plant nutrition diagnosis.
http://dx.doi.org/10.21577/0103-5053
Determination of Target Pesticide Residues in Tropical Fruits Employing Matrix Solid-Phase Dispersion (MSPD) Extraction FollowedGas Chromatography
- Braz. Chem. So
Silvia S. Freitas; Felipe A. T. Serafim; Fernando M. Lanças
Pesticides are undesirable contaminants often present in food samples, particularly in fruits. A preliminary step (extraction) is conducted to transfer the pesticides from the originmatrix solid-phase dispersion (MSPD) was used) to a chromatographic system (in this paper gas chromatography with electron-capture detection (GC-ECD) was used) in ordcompounds.
http://dx.doi.org/10.21577/0103-5053.20180041
Chemical Synthesis
Computer-Guided Total Synthesis of Natural Products. Recent Examples and Future Perspectives
- Braz. Chem. So
Franco Della-Felice; Ronaldo A. Pilli; Ariel M. Sarotti
The use of nuclear magnetic resonance (NMR) calculations can facilitate the total synthesis of natural products of uncertain structural assignment.
http://dx.doi.org/10.21577/0103-5053.20180027
Chemistry Education
RELAÇÕES PEDAGÓGICAS EM AULAS DE CIÊNCIAS DA EDUCAÇÃO SUPERIOR
Quim. N
Ana Luiza de Quadros; Ariane Suelen Freitas Silva; Eduardo Fleury Mortimer
This figure illustrates a pedagogical link-making in the context of teaching and learning scientific conceptual knowledge.
http://dx.doi.org/10.21577/0100-4042.20170178
PHENOMENOLOGICAL APPROACHES TO STUDY LEARNING IN THE TERTIARY LEVEL CHEMISTRY LABORATORY
Quim. N
Santiago Sandi-Urena
Phenomenological studies allow a thorough description of laboratory learning environments. Through its analysis researchers gather a better understanding of how learning in thinforms pedagogical decisions and the design of curricular reforms.
http://dx.doi.org/10.21577/0100-4042.20170176
Energy, Water and Environmental Sciences
Advances of Submarine Groundwater Discharge Studies in South America
- Braz. Chem.
Mariele Paiva; Felipe H. Niencheski
Submarine groundwater discharge plays an important role on the biogeochemistry of the oceans. How much do we know about this process in South America?
http://dx.doi.org/10.21577/0103-5053.20170220
Electrochemical Systems for Renewable Energy Conversion from Salinity and Proton Gradients
- Braz. Chem.
William G. Morais; Gilberto Lima; Wellington J. A. S. Gomes; Fritz Huguenin
Working principle and electrode materials of electrochemical systems for energy conversion from proton and salt gradient.
http://dx.doi.org/10.21577/0103-5053.20180008
Fundamental Consideration for Electrochemical Engineering of Supercapattery
- Braz. Chem.
Bamidele Akinwolemiwa; George Z. Chen
Supercapattery is a generic term for a large number of hybrid electrochemical energy storage devices that combine the merits of supercapacitor and rechargeable battery. imperative to understand the charge storage mechanisms in the electrodes so that high voltage and space-material efficient stack of multiple cells can be manufactured witcommercial affordability.
http://dx.doi.org/10.21577/0103-5053.20180010
Grafting of Quinones on Carbons as Active Electrode Materials in Electrochemical Capacitors
- Braz. Chem.
Thierry Brousse; Charles Cougnon; Daniel Bélanger
Grafting quinone molecules on porous carbons improves their charge storage properties for application as electrode in energy storage systems.
http://dx.doi.org/10.21577/0103-5053.20180015
CO Tolerance and Stability of Proton Exchange Membrane Fuel Cells with Nafion® and Aquivion® Membranes and Mo‑Based Ano
- Braz. Chem. So
Renato C. Iezzi; Rapher D. M. Santos; Gabriel C. da Silva; Valdecir A. Paganin; Edson A. Ticianelli
Cell performance decay after catalyst accelerated aging cyclings: unchanged Pt particles in the anode.
http://dx.doi.org/10.21577/0103-5053.20170230
Green Chemistry and Biotechnology
Determination of Enantioselectivities by Means of Chiral Stationary Phase HPLC in Order to Identify Effective Proline-Derived Orga
Braz. Chem.
Jorge Vargas-Caporali; Eusebio Juaristi
Chiral HPLC (high performance liquid chromatography) constitutes a central part in the evaluation of the organocatalytic potential of new ligands in prototypical asymmetric reaccorrelates in a wordplay a high ee (enantiomeric excess) chromatogram with a good Cat* (catalyst) and a racemic chromatogram with an unsatisfactory Cat*.
http://dx.doi.org/10.21577/0103-5053.20170211
Production of Furan Compounds from Sugarcane Bagasse Using a Catalytic System Containing ZnCl2/HCl or AlCl3/HCl in a Biphas
Braz. Chem. So
Gustavo R. Gomes; Daniel S. Rampon; Luiz P. Ramos
Cellulosic materials and sugarcane bagasse polysaccharides were converted to furan compounds using ZnCl2/HCl or AlCl3/HCl in a biphasic system.
http://dx.doi.org/10.21577/0103-5053.20180014
Simultaneous Multienzymatic Screening with Fluorogenic Probes
Braz. Chem. So
Maria L. S. O. Lima; Michel R. B. Chaves; Renato M. C. do Nascimento; Caroline C. S. Gonçalves; Anita J. Marsaioli
Multienzymatic screening is an interesting and promising methodology that makes possible the simultaneous monitoring of two or more enzymatic activities, in the same microprobes with different emission wavelengths.
http://dx.doi.org/10.21577/0103-5053.20170188
Inorganic and Structural Chemistry
Green Processing of Strategic Elements Based on Magnetic Nanohydrometallurgy
- Braz. Chem.
Ulisses Condomitti; Sabrina N. Almeida; Alceu T. Silveira Jr.; Fernando M. de Melo; Henrique E. Toma
Separation of strategic elements based on magnetic nanohydrometallurgy.
http://dx.doi.org/10.21577/0103-5053.20180009
Macromolecules and Materials
Functionalization of P3HT with Various Mono- and Multidentate Anchor Groups
- Braz. Chem. So
Florian Menk; Ana Fokina; Bernd Oschmann; Tobias A. Bauer; Yannick Nyquist; Lydia Braun; Jonathan Kiehl; Rudolf Zentel
To functionalize inorganic nanoparticles (TiO2 and CdSe) P3HT was synthesized and modified with various mono- and multidentate anchor groups via “click”-reaction.
http://dx.doi.org/10.21577/0103-5053.20170186
Medicinal Chemistry and Chemical Biology
Ditryptophan Cross-Links as Novel Products of Protein Oxidation
Braz. Chem.
Verônica Paviani; Gabriel T. Galdino; Janaina N. dos Prazeres; Raphael F. Queiroz; Ohara Augusto
The formation of ditryptophan cross-links during the oxidation of proteins by biological agents and/or environmental factors is becoming recognized and deserves the attention of m
http://dx.doi.org/10.21577/0103-5053.20170239
Development of Web and Mobile Applications for Chemical Toxicity Prediction
- Braz. Chem.
Vinicius M. Alves; Rodolpho C. Braga; Eugene Muratov; Carolina H. Andrade
General workfl ow for the development and implementation of quantitative structure-activity relationships (QSAR) models in web and mobile applications.
http://dx.doi.org/10.21577/0103-5053.20180013
Total Synthesis of Altissimacoumarin D, a Small Molecule Sirtuin1 Activator
- Braz. Chem. So
Anna C. Silva; Hanae Benelkebir; Rosangela S. C. Lopes; Claudio C. Lopes; A. Ganesan
The total synthesis of the Sirtuin1 activator altissimacoumarin D was accomplished in six steps from 2,4-dihydroxybenzaldehyde.
http://dx.doi.org/10.21577/0103-5053.20180021
Nano Science and Technology
Nanopharmaceuticals and Their Applications in Bladder Cancer Therapy: a Mini Review
- Braz. Chem.
Nelson Durán; Wagner J. Fávaro
Graphene oxide (GO) and a nanostructured lipid carrier (NLC) carrying doxorubicin (DOX) were eff ective on
in vivo treatment of non-muscle invasive bladder cancer (NMIBC) witsilencing oncogenes via small interfering RNA (siRNA).
http://dx.doi.org/10.21577/0103-5053.20180011
Electrodeposition of Prussian Blue/Carbon Nanotube Composites at a Liquid‑Liquid Interface
- Braz. Chem. So
Samantha Husmann; Samuel G. Booth; Aldo J. G. Zarbin; Robert A. W. Dryfe
Prussian Blue electrodeposition over a carbon nanotube fi lm assembled at a liquid-liquid interface has been monitored by in situ Raman spectroscopy.
http://dx.doi.org/10.21577/0103-5053.20180024
Natural Products and Biodiversity
Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rew
Braz. Chem. S
Laura P. Ióca; Karen J. Nicacio; Roberto G. S. Berlinck
Natural products from marine macro- and microorganisms in Brazil encompass a variety of metabolic classes, including complex alkaloids and polyketides, many of which present phave been the subject of synthetic and biosynthetic investigations.
http://dx.doi.org/10.21577/0103-5053.20180016
An Environmentally Friendly Procedure to Obtain Flavonoids From Brazilian Citrus Waste
- Braz. Chem. So
Barbara S. Bellete; Luize Z. Ramin; Deyvid Porto; Alany I. Ribeiro; Moacir R. Forim; Vânia G. Zuin; João B. Fernandes; Maria Fátima G. F. Silva
Brazilian citrus waste can be an attractive source of various flavonoids. The rich diversity and quantity of flavonoids in this residual biomass opens up new opportunities in termconsidering a greater perspective of process valorization.
http://dx.doi.org/10.21577/0103-5053.20180020
Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper gaudichaudianum
- Braz. Chem. So
Andrea N. L. Batista; João M. Batista Jr.; Tatiana M. Souza‑Moreira; Sandro R. Valentini; Massuo J. Kato; Cleslei F. Zanelli; Maysa Furlan
Transcriptomics reveals the biosynthetic origin of p-hydroxybenzoic acid in Piper gaudichaudianum.
http://dx.doi.org/10.21577/0103-5053.20170238
Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
- Braz. Chem. So
Rodrigo M. da Silva; Thais Guaratini; Paula C. Jimenez; William Fenical; Letícia V. Costa-Lotufo; Ricardo Vessecchi; Norberto P. Lopes
Gas phase dissociation reactions study of the anticancer candidate seriniquinone isolated from marine bacterium established by electrospray ionization tandem mass spectrometry
http://dx.doi.org/10.21577/0103-5053.20180037
