⚛️ QN Volume 49, Artigo em Destaque de Novembro! ⚛️
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🔗 Acesse o nosso website: https://quimicanova.sbq.org.br/
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📖 Artigo em Destaque: GC-MS na Metabolômica Clínica: Fundamentos e Fluxo de Trabalho
📌 Autores: Tayná de Oliveira Costa; Gisele A. B. Canuto; Ryland T. Giebelhaus; Murilo de Oliveira Souza
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This review discusses the main workflows used in gas chromatography-mass spectrometry (GC-MS)-based clinical metabolomics to investigate metabolic changes associated with physiological and pathological conditions. It covers study design, sample preparation, chemical derivatization, quality control, instrumental analysis, and data processing. Particular attention is given to methodological challenges that may affect data quality, reliability, and reproducibility, emphasizing the importance of integrated quality management throughout the analytical process.
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🔗 https://doi.org/10.21577/0100-4042.20260113